Letter for the article Distribution and Drug Resistance of Pathogenic


Narinder Kaur,1 Nitin Kumar,2 Harit Kumar1

1Department of Microbiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar University (deemed to be) Mullana, Ambala, Haryana, India; 2Department of Microbiology, Symbiosis Medical College for Women, Symbiosis International (Deemed University) (SIU), Pune, Maharashtra, India

Correspondence: Harit Kumar, Email [email protected]

See the original article by Dr. Pan and colleagues

Mr Editor

Bacteremia (BSI) is always life threatening and causes high mortality if left untreated.1 We read a recently published study titled “Distribution and Drug Resistance of Pathogenic Bacteria and Prognosis in Patients with Septicemia Bloodstream Infection with Renal Insufficiency” with keen interest in whether there is a significant association between bacteria and sepsis with renal insufficiency. .2

Although the authors have done a lot of work, several points need to be reviewed urgently:

  1. The authors, in Table 2, have written two microorganisms; Glucococcus aureus and Pseudomonas albicans, which are misnomers and should never be included in scientific literature.
  2. The authors failed to mention the correct blood culture procedure. Moreover, the separation of serum from the blood sample and the subsequent inoculation of a bacterial drop on a culture plate somehow confirms that the precise blood culture procedure was not followed in this study.3
  3. The authors, in this study, assessed the antibiotic susceptibility pattern of various bacterial strains using the Kirby-Bauer disk diffusion method according to the guidelines of CLSI, 2015.4 However, the following antibiotic-bacteria combinations are not recommended according to the CLSI (Table 1).
  4. The authors reported that 66.67% of isolates of Streptococcus pneumoniae were resistant to penicillin. However, the CLSI does not recommend declaring people resistant to penicillin S.pneumoniae based on the disk diffusion method.5

Table 1 Antibiotic-bacteria combinations are not recommended according to CLSI


The authors declare no conflict of interest in this communication.


1. Kaur N, Kumar H, Bala R, et al. Prevalence of extended-spectrum beta-lactamase and carbapenemase producers in gram-negative bacteria causing blood infection in intensive care unit patients. J Clin Diagn Res. 2021;15(11):DC04–DC07.

2. Pan D, Peng P, Fang Y, Lu J, Fang M. Distribution and drug resistance of pathogenic bacteria and prognosis in blood infection sepsis patients with renal failure. Infect drug resistance. 2022;15:4109–4116. doi:10.2147/IDR.S373665

3. Ransom EM, Alipour Z, Wallace MA, Burnham CA, Simner PJ. Evaluation of optimal blood culture incubation time to maximize clinically relevant results from a contemporary blood culture instrument and media system. J Clin Microbiol. 2021;59(3):e02459–20. doi:10.1128/JCM.02459-20

4.CLSI. Performance standards for antimicrobial susceptibility testing; Twenty-fifth information supplement. CLSI Document M100-S25. Wayne, PA: Clinical and Laboratory Standards Institute; 2015.

5. Kumar N, Kumar H. Intrinsic resistance: an important feature in assessing antibiotic susceptibility pattern [Letter]. Infect drug resistance. 2022;15:1515–1516. doi:10.2147/IDR.S364959

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